Sandbox Reserved 695: Difference between revisions
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The channel protein mostly interacts with sodium ions under normal circumstances, but the activity of the antiepileptic drugs is obviously and important exception to be considered. The sodium ions are conveyed through the channel by favorable interactions with the <scene name='Sandbox_Reserved_695/Vgsc_anionic/1'>anionic redidues</scene>, in particular, the <font color='red'>glutamic acid residues</font> that line the channel helix. | The channel protein mostly interacts with sodium ions under normal circumstances, but the activity of the antiepileptic drugs is obviously and important exception to be considered. The sodium ions are conveyed through the channel by favorable interactions with the <scene name='Sandbox_Reserved_695/Vgsc_anionic/1'>anionic redidues</scene>, in particular, the <font color='red'>glutamic acid residues</font> that line the channel helix. | ||
Interestingly enough, several antiepileptic drugs that are known to work by altering VGSC activity have rather distinctive structures. Phenytoin, carbamazepine, and lamotrigine have rather different structures in three-dimensional space[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=2981395_zmo0101062060001.jpg]. | Interestingly enough, several antiepileptic drugs that are known to work by altering VGSC activity have rather distinctive structures. Phenytoin, carbamazepine, and lamotrigine have rather different structures in three-dimensional space[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=2981395_zmo0101062060001.jpg](click the link for an excellent illustration). | ||
==Active Site== | ==Active Site== | ||
