G1SecL05: Difference between revisions
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<Structure load='1fj1' size='600' frame='true' align='right' caption='3D Jmol model' | <Structure load='1fj1' size='600' frame='true' align='right' caption='3D Jmol model' | ||
scene='Insert optional scene name here' /> | scene='Insert optional scene name here' /> | ||
<scene name='G1SecL05/1fj1_chains_labeled/4'>Model with all chains labeled</scene> | <scene name='G1SecL05/1fj1_chains_labeled/4'>Model with all chains labeled</scene>- | ||
<scene name='G1SecL05/1fj1-condensed/4'>Chain E</scene>-<scene name='G1SecL05/1fj1-condensed/3'>Close up view</scene> | |||
===Trp-216=== | ===Trp-216=== | ||
One hyper-variable region is the Tryptophan amino acid residue sequence 216. Polar amino acid side chains flank the Tryptophan, and changes in such amino acids can ultimately affect the reactivity of OspA to monoclonal antibodies. Differences in side chains of amino acids on the polar surface of a helical structure surrounding the highly conserved tryptophan residue 216 can affect the reactivity of OspA. | One hyper-variable region is the Tryptophan amino acid residue sequence 216. Polar amino acid side chains flank the Tryptophan, and changes in such amino acids can ultimately affect the reactivity of OspA to monoclonal antibodies. Differences in side chains of amino acids on the polar surface of a helical structure surrounding the highly conserved tryptophan residue 216 can affect the reactivity of OspA. | ||
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===Residues 217-237=== | ===Residues 217-237=== | ||
The binding of OspA and the LA-2 FAB is defined by the amino acid residue sequence 217-237, and causes nonspecific binding thus inhibiting the LA2-FAB-OspA complex binding to other species of Borrelia. | The binding of OspA and the LA-2 FAB is defined by the amino acid residue sequence 217-237, and causes nonspecific binding thus inhibiting the LA2-FAB-OspA complex binding to other species of Borrelia. | ||
==Literature References== | ==Literature References== | ||
