G1SecL05: Difference between revisions
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Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | ||
<Structure load='1fj1' size=' | <Structure load='1fj1' size='450' frame='true' align='right' caption='3D Jmol model' | ||
scene='Insert optional scene name here' /> | scene='Insert optional scene name here' /> | ||
<scene name='G1SecL05/1fj1_chains_labeled/4'>Label All Chains</scene>--- | <scene name='G1SecL05/1fj1_chains_labeled/4'>Label All Chains</scene>---<scene name='G1SecL05/1fj1-condensed/5'>Show Only Chain E</scene> | ||
<scene name='G1SecL05/1fj1-condensed/ | ---<scene name='G1SecL05/1fj1-condensed/3'>Close up view</scene> | ||
===Trp-216=== | ===Trp-216=== | ||
One hyper-variable region is the Tryptophan amino acid residue sequence 216. Polar amino acid side chains flank the Tryptophan, and changes in such amino acids can ultimately affect the reactivity of OspA to monoclonal antibodies. Differences in side chains of amino acids on the polar surface of a helical structure surrounding the highly conserved tryptophan residue 216 can affect the reactivity of OspA. | One hyper-variable region is the Tryptophan amino acid residue sequence 216. Polar amino acid side chains flank the Tryptophan, and changes in such amino acids can ultimately affect the reactivity of OspA to monoclonal antibodies. Differences in side chains of amino acids on the polar surface of a helical structure surrounding the highly conserved tryptophan residue 216 can affect the reactivity of OspA. | ||
