2fzb: Difference between revisions

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[[Image:2fzb.gif|left|200px]]<br /><applet load="2fzb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2fzb.gif|left|200px]]
caption="2fzb, resolution 1.50&Aring;" />
 
'''Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.'''<br />
{{Structure
|PDB= 2fzb |SIZE=350|CAPTION= <scene name='initialview01'>2fzb</scene>, resolution 1.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=TOL:TOLRESTAT'>TOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21]
|GENE= ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2FZB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=TOL:'>TOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZB OCA].  
2FZB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZB OCA].  


==Reference==
==Reference==
Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions., Steuber H, Zentgraf M, Gerlach C, Sotriffer CA, Heine A, Klebe G, J Mol Biol. 2006 Oct 13;363(1):174-87. Epub 2006 Aug 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16952371 16952371]
Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions., Steuber H, Zentgraf M, Gerlach C, Sotriffer CA, Heine A, Klebe G, J Mol Biol. 2006 Oct 13;363(1):174-87. Epub 2006 Aug 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16952371 16952371]
[[Category: Aldehyde reductase]]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: tim barrel]]
[[Category: tim barrel]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:38 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:58:36 2008''
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