SB2013 L04gr5: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
=VlsE= | =VlsE= | ||
[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is the most pervasive tick-borne disease in Europe, the United States, and parts of Asia (Couette et al. 2009). It is a multistage infection caused by the spirochete [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Early symptoms include headaches, depression, rash, and fever. If Lyme disease is left untreated serious complications of the joints, heart and central nervous system can occur. Infected Ixodes ticks in their nymph stage transmit Lyme disease by attaching to humans and other mammals (Lab tutor). In most cases, the tick must be attached for 36-48 hours before the bacteria can be transmitted (CDC website). | [http://en.wikipedia.org/wiki/Lyme_disease Lyme disease] is the most pervasive tick-borne disease in Europe, the United States, and parts of Asia (Couette et al. 2009). It is a multistage infection caused by the spirochete [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Early symptoms include headaches, depression, rash, and fever. If Lyme disease is left untreated serious complications of the joints, heart and central nervous system can occur. Infected [http://en.wikipedia.org/wiki/Ixodes Ixodes ticks] in their nymph stage transmit Lyme disease by attaching to humans and other mammals (Lab tutor). In most cases, the tick must be attached for 36-48 hours before the bacteria can be transmitted (CDC website). | ||
Vmp-like sequence Expressed protein (VlsE), is a lipoprotein on the surface of Borrelia burgdorferi. VlsE contributes to the immune evasion and persistence of Lyme disease (Couette et al. 2009). VlsE contains invaraible and varaible domains. It was found that the varaible domain is highly immunogenic and the target of the immune response; however, through antigenic variation the lipoprotein is able to evade the host immune system (Liang et al. 1999). | Vmp-like sequence Expressed protein (VlsE), is a lipoprotein on the surface of Borrelia burgdorferi. VlsE contributes to the immune evasion and persistence of Lyme disease (Couette et al. 2009). VlsE contains invaraible and varaible domains. It was found that the varaible domain is highly immunogenic and the target of the immune response; however, through antigenic variation the lipoprotein is able to evade the host immune system (Liang et al. 1999). | ||
