2g25: Difference between revisions

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[[Image:2g25.gif|left|200px]]<br /><applet load="2g25" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2g25.gif|left|200px]]
caption="2g25, resolution 2.10&Aring;" />
 
'''E. Coli Pyruvate Dehydrogenase Phosphonolactylthiamin Diphosphate Complex'''<br />
{{Structure
|PDB= 2g25 |SIZE=350|CAPTION= <scene name='initialview01'>2g25</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=TDK:3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM'>TDK</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1]
|GENE= aceE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''E. Coli Pyruvate Dehydrogenase Phosphonolactylthiamin Diphosphate Complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2G25 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=TDK:'>TDK</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G25 OCA].  
2G25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G25 OCA].  


==Reference==
==Reference==
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct., Arjunan P, Sax M, Brunskill A, Chandrasekhar K, Nemeria N, Zhang S, Jordan F, Furey W, J Biol Chem. 2006 Jun 2;281(22):15296-303. Epub 2006 Mar 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16531404 16531404]
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct., Arjunan P, Sax M, Brunskill A, Chandrasekhar K, Nemeria N, Zhang S, Jordan F, Furey W, J Biol Chem. 2006 Jun 2;281(22):15296-303. Epub 2006 Mar 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16531404 16531404]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Pyruvate dehydrogenase (acetyl-transferring)]]
[[Category: Pyruvate dehydrogenase (acetyl-transferring)]]
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[[Category: pyruvate dehydrogenase e1 component]]
[[Category: pyruvate dehydrogenase e1 component]]


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