2m75: Difference between revisions
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{{STRUCTURE_2m75| PDB=2m75 | SCENE= }} | |||
===The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | |||
==About this Structure== | |||
[[2m75]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M75 OCA]. | |||
[[Category: Calloselasma rhodostoma]] | |||
[[Category: Chang, Y.]] | |||
[[Category: Chuang, W.]] | |||
[[Category: Shiu, J.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Rhodostomin mutant protein]] | |||
Revision as of 06:22, 20 June 2013
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins
Function
[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
About this Structure
2m75 is a 1 chain structure with sequence from Calloselasma rhodostoma. Full experimental information is available from OCA.
