4bkw: Difference between revisions
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{{STRUCTURE_4bkw| PDB=4bkw | SCENE= }} | |||
===Crystal structure of the C-terminal region of human ZFYVE9=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ZFYV9_HUMAN ZFYV9_HUMAN]] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.<ref>PMID:9865696</ref> <ref>PMID:15356634</ref> | |||
==About this Structure== | |||
[[4bkw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKW OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Bullock, A.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Krojer, T.]] | |||
[[Category: Shrestha, L.]] | |||
[[Category: Vollmar, M.]] | |||
[[Category: Williams, E.]] | |||
[[Category: Protein interaction domain]] | |||
[[Category: Receptor]] | |||
[[Category: Sgc]] | |||
[[Category: Tgf-beta and egfr signalling]] | |||
Revision as of 07:28, 16 May 2013
Crystal structure of the C-terminal region of human ZFYVE9
Function
[ZFYV9_HUMAN] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.[1] [2]
About this Structure
4bkw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998 Dec 11;95(6):779-91. PMID:9865696
- ↑ Lin HK, Bergmann S, Pandolfi PP. Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11. PMID:15356634 doi:10.1038/nature02783
