4bkx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4bkx" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4bkx| PDB=4bkx | SCENE= }} | |||
===The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex=== | |||
{{ABSTRACT_PUBMED_23791785}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MTA1_HUMAN MTA1_HUMAN]] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. | |||
==About this Structure== | |||
[[4bkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKX OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023791785</ref><references group="xtra"/><references/> | |||
[[Category: Histone deacetylase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Celardo, I.]] | |||
[[Category: Cowley, S M.]] | |||
[[Category: Fairall, L.]] | |||
[[Category: Gordiyenko, Y.]] | |||
[[Category: Millard, C J.]] | |||
[[Category: Robinson, C V.]] | |||
[[Category: Schwabe, J W.R.]] | |||
[[Category: Watson, P J.]] | |||
[[Category: Elm2-sant domain]] | |||
[[Category: Hdac]] | |||
[[Category: Hdac1]] | |||
[[Category: Histone deacetylase]] | |||
[[Category: Inositol phosphate signalling]] | |||
[[Category: Mta1]] | |||
[[Category: Transcription]] | |||
Revision as of 13:58, 3 July 2013
The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
Template:ABSTRACT PUBMED 23791785
Function
[MTA1_HUMAN] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
About this Structure
4bkx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW. Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol Cell. 2013 Jun 19. pii: S1097-2765(13)00407-3. doi:, 10.1016/j.molcel.2013.05.020. PMID:23791785 doi:10.1016/j.molcel.2013.05.020
