4k8v: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4k8v|  PDB=4k8v  |  SCENE=  }}
+===Structure of cyclic GMP-AMP Synthase (cGAS)===
-The entry 4k8v is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
-Authors: Gao, P., Wu, Y., Patel, D.J.
+==About this Structure==
+[[4k8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8V OCA].
-Description: Structure of cyclic GMP-AMP Synthase (cGAS)
+[[Category: Mus musculus]]
+[[Category: Gao, P.]]
+[[Category: Patel, D J.]]
+[[Category: Wu, Y.]]
+[[Category: Dna]]
+[[Category: Nucleotidyltransferase]]
+[[Category: Transferase]]

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