4k99: Difference between revisions
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{{STRUCTURE_4k99| PDB=4k99 | SCENE= }} | |||
===Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | |||
==About this Structure== | |||
[[4k99]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K99 OCA]. | |||
[[Category: Mus musculus]] | |||
[[Category: Gao, P.]] | |||
[[Category: Patel, D J.]] | |||
[[Category: Wu, Y.]] | |||
[[Category: Nucleotidyltransferase fold]] | |||
[[Category: Transferase-dna complex]] | |||
Revision as of 07:34, 16 May 2013
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4k99 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
