4k9h: Difference between revisions
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{{STRUCTURE_4k9h| PDB=4k9h | SCENE= }} | |||
===Bace-1 inhibitor complex=== | |||
{{ABSTRACT_PUBMED_23769639}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | |||
[[4k9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K9H OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023769639</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | |||
[[Category: Jordan, S R.]] | |||
[[Category: Aspartic protease]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Protease]] | |||
