4kcc: Difference between revisions
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{{STRUCTURE_4kcc| PDB=4kcc | SCENE= }} | |||
===Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> | |||
==About this Structure== | |||
[[4kcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCC OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Berger, A J.]] | |||
[[Category: Lau, A Y.]] | |||
[[Category: Mayer, M L.]] | |||
[[Category: Membrane protein]] | |||
Revision as of 05:22, 1 August 2013
Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State
Function
[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1]
About this Structure
4kcc is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022
