2g9c: Difference between revisions
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[[Image:2g9c.gif|left|200px]] | [[Image:2g9c.gif|left|200px]] | ||
'''Modified pyrimidines Specifically bind the purine riboswitch''' | {{Structure | ||
|PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene> and <scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Modified pyrimidines Specifically bind the purine riboswitch''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2G9C is a [ | 2G9C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. | ||
==Reference== | ==Reference== | ||
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http:// | Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Batey, R T.]] | [[Category: Batey, R T.]] | ||
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[[Category: triaminopyrimidine]] | [[Category: triaminopyrimidine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:01 2008'' | ||
Revision as of 15:02, 20 March 2008
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| 2g9c, resolution 1.70Å | |||||||||||||
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| Ligands: | ACT, NCO and 3AY | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Modified pyrimidines Specifically bind the purine riboswitch
Overview
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
About this Structure
2G9C is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468
Page seeded by OCA on Thu Mar 20 17:02:01 2008
