2g94: Difference between revisions

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[[Image:2g94.gif|left|200px]]~~<br /><applet load~~="2g94~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2g94.gif|left|200px]]

~~caption="~~2g94, resolution 1.86Å" />

'''Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.'''~~<br />~~

{{Structure

|PDB= 2g94 |SIZE=350|CAPTION= <scene name='initialview01'>2g94</scene>, resolution 1.86Å

|SITE=

|LIGAND= <scene name='pdbligand=ZPQ:N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE'>ZPQ</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]

|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.'''

==Overview==

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==About this Structure==

2G94 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] ~~with <scene name='pdbligand=ZPQ:'>ZPQ</scene> as [http://en.wikipedia~~.~~org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G94 OCA].

2G94 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G94 OCA].

==Reference==

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors., Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~16620080 16620080]

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors., Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16620080 16620080]

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

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[[Category: protease inhibitor]]

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@@ Line 1: / Line 1: @@
-[[Image:2g94.gif|left|200px]]<br /><applet load="2g94" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2g94.gif|left|200px]]
-caption="2g94, resolution 1.86&Aring;" />
-'''Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.'''<br />
+ {{Structure
+|PDB= 2g94 |SIZE=350|CAPTION= <scene name='initialview01'>2g94</scene>, resolution 1.86&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZPQ:N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE'>ZPQ</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]
+|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-G94 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZPQ:'>ZPQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G94 OCA].
+G94 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G94 OCA].
 ==Reference==
-Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors., Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16620080 16620080]
+Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors., Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Am Chem Soc. 2006 Apr 26;128(16):5310-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16620080 16620080]
 [[Category: Homo sapiens]]
 [[Category: Memapsin 2]]
@@ Line 27: / Line 36: @@
 [[Category: protease inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:01:51 2008''