4jr2: Difference between revisions
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{{STRUCTURE_4jr2| PDB=4jr2 | SCENE= }} | {{STRUCTURE_4jr2| PDB=4jr2 | SCENE= }} | ||
===Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK=== | ===Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK=== | ||
{{ABSTRACT_PUBMED_23650375}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4jr2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR2 OCA]. | [[4jr2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR2 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023650375</ref><references group="xtra"/><references/> | |||
[[Category: Caspase-7]] | [[Category: Caspase-7]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 15:37, 19 June 2013
Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK
Template:ABSTRACT PUBMED 23650375
Function
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this Structure
4jr2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Thomsen ND, Koerber JT, Wells JA. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8477-82. doi:, 10.1073/pnas.1306759110. Epub 2013 May 6. PMID:23650375 doi:10.1073/pnas.1306759110
