2gal: Difference between revisions
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[[Image:2gal.gif|left|200px]] | [[Image:2gal.gif|left|200px]] | ||
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE''' | {{Structure | ||
|PDB= 2gal |SIZE=350|CAPTION= <scene name='initialview01'>2gal</scene>, resolution 2.00Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2GAL is a [ | 2GAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAL OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:[http:// | Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9760227 9760227] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:02:24 2008'' | ||
Revision as of 15:02, 20 March 2008
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| 2gal, resolution 2.00Å | |||||||||||||
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| Ligands: | GAL | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE
Overview
Knowledge about carbohydrate recognition domains of galectins, formerly known as S-type animal lectins, is important in understanding their role(s) in cell-cell interactions. Here we report the crystal structure of human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This is the first structure of a galectin determined in both free and carbohydrate-bound forms. The structure shows a fold similar to that of the prototype galectins -1 and -2, but has greater similarity to a related galectin molecule, Gal-10. Even though the carbohydrate-binding residues are conserved, there are significant changes in this pocket due to shortening of a loop structure. The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition.
About this Structure
2GAL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227
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