3q7k: Difference between revisions
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==Formate Channel FocA from Salmonella typhimurium== | |||
=== | <StructureSection load='3q7k' size='340' side='right' caption='[[3q7k]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3q7k]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q7K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">focA, STY0974, t1960 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 Salmonella enterica subsp. enterica serovar Typhi])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q7k RCSB], [http://www.ebi.ac.uk/pdbsum/3q7k PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The formate transporter FocA was described to switch its mode of operation from a passive export channel at high external pH to a secondary active formate/H(+) importer at low pH. The crystal structure of Salmonella typhimurium FocA at pH 4.0 shows that this switch involves a major rearrangement of the amino termini of individual protomers in the pentameric channel. The amino-terminal helices open or block transport in a concerted, cooperative action that indicates how FocA is gated in a pH-dependent way. Electrophysiological studies show that the protein acts as a specific formate channel at pH 7.0 and that it closes upon a shift of pH to 5.1. | |||
pH-dependent gating in a FocA formate channel.,Lu W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O Science. 2011 Apr 15;332(6027):352-4. PMID:21493860<ref>PMID:21493860</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Salmonella enterica subsp. enterica serovar typhi]] | [[Category: Salmonella enterica subsp. enterica serovar typhi]] | ||
[[Category: Andrade, S L.A | [[Category: Andrade, S L.A]] | ||
[[Category: Du, J | [[Category: Du, J]] | ||
[[Category: Einsle, O | [[Category: Einsle, O]] | ||
[[Category: Gerbig-Smentek, E | [[Category: Gerbig-Smentek, E]] | ||
[[Category: Lue, W | [[Category: Lue, W]] | ||
[[Category: Wacker, T | [[Category: Wacker, T]] | ||
[[Category: Cytoplasmic membrane]] | [[Category: Cytoplasmic membrane]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Transport]] | [[Category: Transport]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 10:10, 19 December 2014
Formate Channel FocA from Salmonella typhimurium
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