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{{STRUCTURE_3q93|  PDB=3q93  |  SCENE=  }}
==Crystal Structure of Human 8-oxo-dGTPase (MTH1)==
===Crystal Structure of Human 8-oxo-dGTPase (MTH1)===
<StructureSection load='3q93' size='340' side='right' caption='[[3q93]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q93 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTH1, NUDT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> 
*[[7%2C8-dihydro-8-oxoguanine triphosphatase|7%2C8-dihydro-8-oxoguanine triphosphatase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Der.]]
[[Category: Berg, S Van Der]]
[[Category: Berglund, H.]]
[[Category: Berglund, H]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Collins, R.]]
[[Category: Collins, R]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Ekblad, T.]]
[[Category: Ekblad, T]]
[[Category: Flodin, S.]]
[[Category: Flodin, S]]
[[Category: Flores, A.]]
[[Category: Flores, A]]
[[Category: Graslund, S.]]
[[Category: Graslund, S]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom, M]]
[[Category: Johansson, I.]]
[[Category: Johansson, I]]
[[Category: Karlberg, T.]]
[[Category: Karlberg, T]]
[[Category: Kol, S.]]
[[Category: Kol, S]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova, T]]
[[Category: Kouznetsova, E.]]
[[Category: Kouznetsova, E]]
[[Category: Moche, M.]]
[[Category: Moche, M]]
[[Category: Nordlund, P.]]
[[Category: Nordlund, P]]
[[Category: Nyman, T.]]
[[Category: Nyman, T]]
[[Category: Persson, C.]]
[[Category: Persson, C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Schuler, H.]]
[[Category: Schuler, H]]
[[Category: Schutz, P.]]
[[Category: Schutz, P]]
[[Category: Siponen, M I.]]
[[Category: Siponen, M I]]
[[Category: Thorsell, A G.]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues, L.]]
[[Category: Tresaugues, L]]
[[Category: Wahlberg, E.]]
[[Category: Wahlberg, E]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Welin, M.]]
[[Category: Welin, M]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Magnesium binding]]
[[Category: Magnesium binding]]
Line 45: Line 47:
[[Category: Nudix]]
[[Category: Nudix]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Revision as of 10:11, 19 December 2014

Crystal Structure of Human 8-oxo-dGTPase (MTH1)

3q93, resolution 1.80Å

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