2gcb: Difference between revisions

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[[Image:2gcb.gif|left|200px]]<br /><applet load="2gcb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gcb.gif|left|200px]]
caption="2gcb, resolution 2.3&Aring;" />
 
'''G51S/S52T double mutant of L. casei FPGS'''<br />
{{Structure
|PDB= 2gcb |SIZE=350|CAPTION= <scene name='initialview01'>2gcb</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND=
|ACTIVITY= [http://en.wikipedia.org/wiki/Tetrahydrofolate_synthase Tetrahydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.17 6.3.2.17]
|GENE= fgs ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
}}
 
'''G51S/S52T double mutant of L. casei FPGS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GCB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Active as [http://en.wikipedia.org/wiki/Tetrahydrofolate_synthase Tetrahydrofolate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.17 6.3.2.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCB OCA].  
2GCB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCB OCA].  


==Reference==
==Reference==
Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops., Smith CA, Cross JA, Bognar AL, Sun X, Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):548-58. Epub 2006, Apr 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16627949 16627949]
Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops., Smith CA, Cross JA, Bognar AL, Sun X, Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):548-58. Epub 2006, Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16627949 16627949]
[[Category: Lactobacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: site-directed mutant]]
[[Category: site-directed mutant]]


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