2kzy: Difference between revisions

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~~{{STRUCTURE_2kzy| PDB=2kzy | SCENE= }}~~

==Solution NMR structure of the ZNF216 A20 zinc finger==

===Solution NMR structure of the ZNF216 A20 zinc finger===

~~{{ABSTRACT_PUBMED_021923101}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZY FirstGlance].

==~~Function~~==

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT~~]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Zfand5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</td></tr>

==~~About this Structure~~==

</table>

[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA].

__TOC__

</StructureSection>

[[Category: Rattus norvegicus]]

[[Category: Garner, T P.]]

[[Category: Garner, T P]]

[[Category: Layfield, R.]]

[[Category: Layfield, R]]

[[Category: Long, J E.]]

[[Category: Long, J E]]

[[Category: Searle, M S.]]

[[Category: Searle, M S]]

[[Category: A20 domain]]

[[Category: Atrogene]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_2kzy|  PDB=2kzy  |  SCENE=  }}
+==Solution NMR structure of the ZNF216 A20 zinc finger==
-===Solution NMR structure of the ZNF216 A20 zinc finger===
+<StructureSection load='2kzy' size='340' side='right' caption='[[2kzy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-{{ABSTRACT_PUBMED_021923101}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZY FirstGlance]. <br>
-==Function==
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zfand5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</span></td></tr>
-==About this Structure==
+</table>
-[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA].
+__TOC__
+</StructureSection>
 [[Category: Rattus norvegicus]]
-[[Category: Garner, T P.]]
+[[Category: Garner, T P]]
-[[Category: Layfield, R.]]
+[[Category: Layfield, R]]
-[[Category: Long, J E.]]
+[[Category: Long, J E]]
-[[Category: Searle, M S.]]
+[[Category: Searle, M S]]
 [[Category: A20 domain]]
 [[Category: Atrogene]]