SB2013 L04gr5: Difference between revisions
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The variable regions’ location also supports the potential role that the protein plays in evading host immune responses through [http://en.wikipedia.org/wiki/Gene_conversion gene conversion] (Zhang and Norris 1998). These regions are hypothesized to expose highly variable [http://en.wikipedia.org/wiki/Epitopes epitopes], which would prevent the immune system from recognizing the antigen and subsequently prevent the onset of Lyme disease (Eicken 2002). This feature starkly contrasts to the invariable regions, which does not undergo constant variation and whose genetic composition remains mostly conserved (Zhang and Norris 1998). | The variable regions’ location also supports the potential role that the protein plays in evading host immune responses through [http://en.wikipedia.org/wiki/Gene_conversion gene conversion] (Zhang and Norris 1998). These regions are hypothesized to expose highly variable [http://en.wikipedia.org/wiki/Epitopes epitopes], which would prevent the immune system from recognizing the antigen and subsequently prevent the onset of Lyme disease (Eicken 2002). This feature starkly contrasts to the invariable regions, which does not undergo constant variation and whose genetic composition remains mostly conserved (Zhang and Norris 1998). | ||
