SB2013 L04gr5: Difference between revisions

Line 8:

=Structure=

The lipoprotein, VlsE, consists of two invariable domains at the amino and carboxyl termini and a variable domain (Figure 1). When referring to the primary structure of the protein, the variable domain is a cassette region located between the two termini. The variable domain can be further broken down into variable regions (<scene name='SB2013_L04gr5/Variable_regions/3'>VRs</scene>) and invariable regions (<scene name='SB2013_L04gr5/Invariable_regions/2'>IRs</scene>) (Liang ~~et al. 1999)~~.

The lipoprotein, VlsE, consists of two invariable domains at the amino and carboxyl termini and a variable domain (Figure 1). When referring to the primary structure of the protein, the variable domain is a cassette region located between the two termini. The variable domain can be further broken down into variable regions (<scene name='SB2013_L04gr5/Variable_regions/3'>VRs</scene>) and invariable regions (<scene name='SB2013_L04gr5/Invariable_regions/2'>IRs</scene>) <ref name="Liang" />.

When crystallized, VlsE forms a four molecule asymmetric unit with each molecule having slight differences in their conformation. Although each molecule in the unit is slightly different, a single molecule of the protein consists of eleven [http://en.wikipedia.org/wiki/Alpha_helices α-helices] and four short [http://en.wikipedia.org/wiki/Beta_strand β-strands]. Helices α1 (aa 306-341), α2 (aa 68-87), α3 (aa 114-139), and α11 (aa 306-341) all form the <scene name='SB2013_L04gr5/Membrane_proximal_region/1'>membrane proximal region</scene> of VlsE, while helices α4 through α10 form the primary region of the <scene name='SB2013_L04gr5/Membrane_distal_region/2'>membrane distal region</scene> of the protein. The four short β-strands each consist of 3 amino acids and can also be located in the membrane distal region.

SB2013 L04gr5: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 8: / Line 8: @@
 <Structure load='1L8W' size='400' frame='true' align='right' caption='Crystallized Structure of VlsE' scene='' />
 =Structure=
-The lipoprotein, VlsE, consists of two invariable domains at the amino and carboxyl termini and a variable domain (Figure 1).  When referring to the primary structure of the protein, the variable domain is a cassette region located between the two termini.  The variable domain can be further broken down into variable regions (<scene name='SB2013_L04gr5/Variable_regions/3'>VRs</scene>) and invariable regions (<scene name='SB2013_L04gr5/Invariable_regions/2'>IRs</scene>) (Liang et al. 1999).
+The lipoprotein, VlsE, consists of two invariable domains at the amino and carboxyl termini and a variable domain (Figure 1).  When referring to the primary structure of the protein, the variable domain is a cassette region located between the two termini.  The variable domain can be further broken down into variable regions (<scene name='SB2013_L04gr5/Variable_regions/3'>VRs</scene>) and invariable regions (<scene name='SB2013_L04gr5/Invariable_regions/2'>IRs</scene>) <ref name="Liang" />.
 When crystallized, VlsE forms a four molecule asymmetric unit with each molecule having slight differences in their conformation.  Although each molecule in the unit is slightly different, a single molecule of the protein consists of eleven [http://en.wikipedia.org/wiki/Alpha_helices α-helices] and four short [http://en.wikipedia.org/wiki/Beta_strand β-strands].  Helices α1 (aa 306-341), α2 (aa 68-87), α3 (aa 114-139), and α11 (aa 306-341) all form the <scene name='SB2013_L04gr5/Membrane_proximal_region/1'>membrane proximal region</scene> of VlsE, while helices α4 through α10 form the primary region of the <scene name='SB2013_L04gr5/Membrane_distal_region/2'>membrane distal region</scene> of the protein.  The four short β-strands each consist of 3 amino acids and can also be located in the membrane distal region.