2gke: Difference between revisions

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[[Image:2gke.gif|left|200px]]<br /><applet load="2gke" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gke.gif|left|200px]]
caption="2gke, resolution 1.35&Aring;" />
 
'''Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP'''<br />
{{Structure
|PDB= 2gke |SIZE=350|CAPTION= <scene name='initialview01'>2gke</scene>, resolution 1.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZDP:(2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC+ACID'>ZDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7]
|GENE= dapF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
}}
 
'''Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae] with <scene name='pdbligand=ZDP:'>ZDP</scene>, <scene name='pdbligand=GOL:'>GOL</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Diaminopimelate_epimerase Diaminopimelate epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.7 5.1.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKE OCA].  
2GKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKE OCA].  


==Reference==
==Reference==
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target., Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN, Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8668-73. Epub 2006 May 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16723397 16723397]
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target., Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN, Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8668-73. Epub 2006 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16723397 16723397]
[[Category: Diaminopimelate epimerase]]
[[Category: Diaminopimelate epimerase]]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: enzyme-inhibitor complex]]
[[Category: enzyme-inhibitor complex]]


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