4bmj: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4bmj" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | |||
===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref> | |||
==About this Structure== | |||
[[4bmj]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Bravo, J.]] | |||
[[Category: Buts, L.]] | |||
[[Category: Ceregido, M A.]] | |||
[[Category: Nuland, N A.J van.]] | |||
[[Category: Rivera, J.]] | |||
[[Category: Spinola-Amilibia, M.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Inflammation]] | |||
[[Category: Ubiquitin]] | |||
[[Category: Ubz domain]] | |||
Revision as of 13:37, 20 November 2013
Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
Function
[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]
About this Structure
4bmj is a 11 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:https://dx.doi.org/10.1038/sj.onc.1202787
- ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:https://dx.doi.org/10.1073/pnas.170279097
