4k88: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form)===

~~The entry 4k88~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>

~~Authors~~: ~~Hwang, K~~.Y.~~, Son, J~~.H.~~, Lee, E~~.H.

==About this Structure==

[[4k88]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K88 OCA].

~~Description~~: ~~Crystal structure of human prolyl~~-tRNA synthetase ~~(halofuginone bound form)~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Proline--tRNA ligase]]

[[Category: Hwang, K Y.]]

[[Category: Lee, E H.]]

[[Category: Son, J H.]]

[[Category: Class ii trna synthetase]]

[[Category: Cytosol]]

[[Category: Ligase]]

[[Category: Ligase-ligase inhibitor complex]]

[[Category: Zinc binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4k88|  PDB=4k88  |  SCENE=  }}
+===Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form)===
-The entry 4k88 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>
-Authors: Hwang, K.Y., Son, J.H., Lee, E.H.
+==About this Structure==
+[[4k88]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K88 OCA].
-Description: Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form)
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Proline--tRNA ligase]]
+[[Category: Hwang, K Y.]]
+[[Category: Lee, E H.]]
+[[Category: Son, J H.]]
+[[Category: Class ii trna synthetase]]
+[[Category: Cytosol]]
+[[Category: Ligase]]
+[[Category: Ligase-ligase inhibitor complex]]
+[[Category: Zinc binding]]