4kfq: Difference between revisions
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{{STRUCTURE_4kfq| PDB=4kfq | SCENE= }} | |||
===Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one=== | |||
{{ABSTRACT_PUBMED_12805203}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> | |||
==About this Structure== | |||
[[4kfq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFQ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:012805203</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Gajhede, M]] | |||
[[Category: Kastrup, J S]] | |||
[[Category: Steffensen, T B]] | |||
[[Category: Tabrizi, F M.]] | |||
[[Category: Ionotropic glutamate receptor]] | |||
[[Category: Ligand binding domain]] | |||
[[Category: Membrane protein]] | |||
Revision as of 06:29, 10 October 2013
Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one
Template:ABSTRACT PUBMED 12805203
Function
[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1]
About this Structure
4kfq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Furukawa H, Gouaux E. Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. EMBO J. 2003 Jun 16;22(12):2873-85. PMID:12805203 doi:10.1093/emboj/cdg303
- ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022
