3sem: Difference between revisions
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Revision as of 07:42, 16 May 2013
SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Template:ABSTRACT PUBMED 9851931
Function
[SEM5_CAEEL] Acts both in vulval induction and sex myoblast migration. Presumably interacts with the kinase receptor let-23 and with a target that modifies the Ras-like protein let-60.
About this Structure
3sem is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931
