4in0: Difference between revisions
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==Crystal Structure of human splicing factor dim2/TXNL4B== | |||
<StructureSection load='4in0' size='340' side='right' caption='[[4in0]], [[Resolution|resolution]] 1.33Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4in0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureorectus Streptomyces aureorectus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IN0 FirstGlance]. <br> | |||
==Function== | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DIM2, DLP, TXNL4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285571 Streptomyces aureorectus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4in0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4in0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4in0 RCSB], [http://www.ebi.ac.uk/pdbsum/4in0 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TXN4B_HUMAN TXN4B_HUMAN]] Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.<ref>PMID:15161931</ref> | [[http://www.uniprot.org/uniprot/TXN4B_HUMAN TXN4B_HUMAN]] Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.<ref>PMID:15161931</ref> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
TXNL4A (thioredoxin-like 4A) is an essential protein conserved from yeast to humans and is a component of the pre-mRNA splicing machinery. TXNL4B was identified as a TXNL4-family protein that also interacts with Prp6, an integral component of the U4/U6.U5 tri-snRNP complex, and has been shown to function in pre-mRNA splicing. A crystal structure of TXNL4B was determined at 1.33 A resolution and refined to an Rwork of 0.13 and an Rfree of 0.18 with one native dimer in the asymmetric unit. Residues 1-33 of TXNL4B have previously been reported to be responsible for its interaction with Prp6. However, this region extends to the beta-sheet core of the thioredoxin-fold structure of TXNL4B. This suggests that the interpretation of the previously reported GST pull-down results without considering the structure and stability of TXNL4B is debatable. | |||
High-resolution crystal structure of human Dim2/TXNL4B.,Jin T, Guo F, Wang Y, Zhang Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):223-7. doi:, 10.1107/S1744309113000973. Epub 2013 Feb 22. PMID:23519793<ref>PMID:23519793</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Streptomyces aureorectus]] | [[Category: Streptomyces aureorectus]] | ||
[[Category: Guo, F | [[Category: Guo, F]] | ||
[[Category: Jin, T C | [[Category: Jin, T C]] | ||
[[Category: Zhang, Y Z | [[Category: Zhang, Y Z]] | ||
[[Category: Pre-mrna splicing]] | [[Category: Pre-mrna splicing]] | ||
[[Category: Splicing]] | [[Category: Splicing]] | ||
Revision as of 10:04, 25 December 2014
Crystal Structure of human splicing factor dim2/TXNL4B
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