3qil: Difference between revisions
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==Crystal structure analysis of the clathrin trimerization domain== | |||
=== | <StructureSection load='3qil' size='340' side='right' caption='[[3qil]], [[Resolution|resolution]] 3.92Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3qil]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QIL FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLTC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qil OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qil RCSB], [http://www.ebi.ac.uk/pdbsum/3qil PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Clathrin is a trimeric protein involved in receptor-mediated-endocytosis, but can function as a non-trimer outside of endocytosis. We have discovered that the subcellular distribution of a clathrin cysteine mutant we previously studied is altered and a proportion is also localized to nuclear spaces. MALS shows C1573A hub is a mixture of trimer-like and detrimerized molecules. The X-ray structure of the trimerization domain reveals that without light chains, a helix harboring cysteine-1573 is reoriented. We propose clathrin has a detrimerization switch, which suggests clathrin topology can be altered naturally for new functions. | |||
Nuclear localization of clathrin involves a labile helix outside the trimerization domain.,Ybe JA, Fontaine SN, Stone T, Nix J, Lin X, Mishra S FEBS Lett. 2013 Jan 16;587(2):142-9. doi: 10.1016/j.febslet.2012.11.005. Epub, 2012 Nov 21. PMID:23178717<ref>PMID:23178717</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Clathrin|Clathrin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Mishra, S | [[Category: Mishra, S]] | ||
[[Category: Nix, J | [[Category: Nix, J]] | ||
[[Category: Ybe, J A | [[Category: Ybe, J A]] | ||
[[Category: Clathrin trimerization domain]] | [[Category: Clathrin trimerization domain]] | ||
[[Category: Endocytosis]] | [[Category: Endocytosis]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 11:01, 19 December 2014
Crystal structure analysis of the clathrin trimerization domain
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