2m49: Difference between revisions
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{{STRUCTURE_2m49| PDB=2m49 | SCENE= }} | |||
===Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction=== | |||
{{ABSTRACT_PUBMED_24063890}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref> [[http://www.uniprot.org/uniprot/S100B_HUMAN S100B_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization.<ref>PMID:20351179</ref> | |||
==About this Structure== | |||
[[2m49]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M49 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024063890</ref><references group="xtra"/><references/> | |||
[[Category: Gupta, A A.]] | |||
[[Category: Yu, C.]] | |||
[[Category: Cytokine-metal binding protein complex]] | |||
[[Category: Fgf2]] | |||
[[Category: S100b]] | |||
