2m8d: Difference between revisions

Line 1:

''~~'Unreleased structure'''~~

===Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'===

~~The entry 2m8d is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>

~~Authors~~: ~~Clery, A~~.~~, Sinha, R~~.~~, Anczukow, O~~.~~, Corrionero, A., Moursy, A., Daubner, G., Valcarcel, J., Krainer, A.R~~.~~, Allain, F~~.H.T.

==About this Structure==

[[2m8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8D OCA].

~~Description~~: ~~Structure of SRSF1 RRM2 in complex with the RNA 5'~~-~~UGAAGGAC~~-3'

==Reference==

[[Category: Homo sapiens]]

[[Category: Allain, F H.T.]]

[[Category: Anczukow, O.]]

[[Category: Clery, A.]]

[[Category: Corrionero, A.]]

[[Category: Daubner, G.]]

[[Category: Krainer, A R.]]

[[Category: Moursy, A.]]

[[Category: Sinha, R.]]

[[Category: Valcarcel, J.]]

[[Category: Pseudo-rrm]]

[[Category: Rna binding protein-rna complex]]

[[Category: Rrm]]

[[Category: Sr protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m8d|  PDB=2m8d  |  SCENE=  }}
+===Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'===
-The entry 2m8d is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>
-Authors: Clery, A., Sinha, R., Anczukow, O., Corrionero, A., Moursy, A., Daubner, G., Valcarcel, J., Krainer, A.R., Allain, F.H.T.
+==About this Structure==
+[[2m8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8D OCA].
-Description: Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Allain, F H.T.]]
+[[Category: Anczukow, O.]]
+[[Category: Clery, A.]]
+[[Category: Corrionero, A.]]
+[[Category: Daubner, G.]]
+[[Category: Krainer, A R.]]
+[[Category: Moursy, A.]]
+[[Category: Sinha, R.]]
+[[Category: Valcarcel, J.]]
+[[Category: Pseudo-rrm]]
+[[Category: Rna binding protein-rna complex]]
+[[Category: Rrm]]
+[[Category: Sr protein]]