3uen: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_3uen|  PDB=3uen  |  SCENE=  }}
+===Crystal structure of TopBP1 BRCT4/5 domains===
-The entry 3uen is ON HOLD  until Jun 30 2014
+==Function==
+[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
-Authors: Leung, C.C., Glover, J.N.M.
+==About this Structure==
+[[3uen]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UEN OCA].
-Description: Crystal structure of TopBP1 BRCT4/5 domains
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Glover, J N.M.]]
+[[Category: Leung, C C.]]
+[[Category: Brct domain]]
+[[Category: Peptide binding protein]]
+[[Category: Phospho-peptide binding]]

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