3w0j: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_3w0j|  PDB=3w0j  |  SCENE=  }}
===Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands===
{{ABSTRACT_PUBMED_23462137}}


The entry 3w0j is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>  [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref> 


Authors: Shimizu, T., Asano, L., Kuwabara, N., Ito, I., Waku, T., Yanagisawa, J., Miyachi, H.
==About this Structure==
[[3w0j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0J OCA].  


Description: Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands
==Reference==
<ref group="xtra">PMID:023462137</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Asano, L.]]
[[Category: Ito, I.]]
[[Category: Kuwabara, N.]]
[[Category: Miyachi, H.]]
[[Category: Shimizu, T.]]
[[Category: Waku, T.]]
[[Category: Yanagisawa, J.]]
[[Category: Gene regulation]]
[[Category: Transcription]]
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