3w9h: Difference between revisions
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{{STRUCTURE_3w9h| PDB=3w9h | SCENE= }} | |||
===Structural basis for the inhibition of bacterial multidrug exporters=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> | |||
==About this Structure== | |||
[[3w9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9H OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Escherichia coli k-12]] | |||
[[Category: Nagata, C.]] | |||
[[Category: Nakashima, R.]] | |||
[[Category: Sakurai, K.]] | |||
[[Category: Yamaguchi, A.]] | |||
[[Category: Acra]] | |||
[[Category: Acrb]] | |||
[[Category: Efflux pump]] | |||
[[Category: Inner membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Multidrug efflux pump]] | |||
[[Category: Tolc]] | |||
[[Category: Transport protein]] | |||
[[Category: Transporter]] | |||
Revision as of 14:12, 3 July 2013
Structural basis for the inhibition of bacterial multidrug exporters
Function
[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]
About this Structure
3w9h is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
- ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
- ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007
