3w9j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structural basis for the inhibition of bacterial multidrug exporters===

The ~~entry 3w9j~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/MEXB_PSEAE MEXB_PSEAE]] The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>

~~Authors~~: ~~Sakurai, K~~.~~, Nakashima, R~~.~~, Hayashi, K~~.~~, Yamaguchi, A~~.

==About this Structure==

[[3w9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9J OCA].

~~Description~~: ~~Structural basis for the inhibition of bacterial multidrug exporters~~

==Reference==

[[Category: Pseudomonas aeruginosa pao1]]

[[Category: Hayashi, K.]]

[[Category: Nakashima, R.]]

[[Category: Sakurai, K.]]

[[Category: Yamaguchi, A.]]

[[Category: Efflux pump]]

[[Category: Inner membrane]]

[[Category: Membrane protein]]

[[Category: Mexa]]

[[Category: Mexb]]

[[Category: Multidrug efflux pump]]

[[Category: Oprm]]

[[Category: Transport protein]]

[[Category: Transporter]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3w9j|  PDB=3w9j  |  SCENE=  }}
+===Structural basis for the inhibition of bacterial multidrug exporters===
-The entry 3w9j is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/MEXB_PSEAE MEXB_PSEAE]] The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>   The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>
-Authors: Sakurai, K., Nakashima, R., Hayashi, K., Yamaguchi, A.
+==About this Structure==
+[[3w9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9J OCA].
-Description: Structural basis for the inhibition of bacterial multidrug exporters
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Pseudomonas aeruginosa pao1]]
+[[Category: Hayashi, K.]]
+[[Category: Nakashima, R.]]
+[[Category: Sakurai, K.]]
+[[Category: Yamaguchi, A.]]
+[[Category: Efflux pump]]
+[[Category: Inner membrane]]
+[[Category: Membrane protein]]
+[[Category: Mexa]]
+[[Category: Mexb]]
+[[Category: Multidrug efflux pump]]
+[[Category: Oprm]]
+[[Category: Transport protein]]
+[[Category: Transporter]]