3wb5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one===

~~The entry 3wb5~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Yonezawa, S~~.~~, Fujiwara, K~~.~~, Yamamoto, T~~.~~, Hattori, K., Yamakawa, H., Muto, C., Hosono, M., Tanaka, Y., Nakano, T~~.~~, Takemoto, H~~.~~, Arisawa, M~~.~~, Shuto, S~~.

==About this Structure==

[[3wb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WB5 OCA].

~~Description~~: ~~Crystal Structure of beta secetase in complex with (6S)-~~2~~-amino-3~~,~~6-dimethyl-6-~~[~~(1R~~,~~2R)-2-phenylcyclopropyl~~]-3,4,5,6-~~tetrahydropyrimidin~~-~~4-one~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

[[Category: Arisawa, M.]]

[[Category: Fujiwara, K.]]

[[Category: Hattori, K.]]

[[Category: Hosono, M.]]

[[Category: Muto, C.]]

[[Category: Nakano, T.]]

[[Category: Shuto, S.]]

[[Category: Takemoto, H.]]

[[Category: Tanaka, Y.]]

[[Category: Yamakawa, H.]]

[[Category: Yamamoto, T.]]

[[Category: Yonezawa, S.]]

[[Category: Asp2]]

[[Category: Hydrolase]]

[[Category: Memapsin-2]]

[[Category: Membrane-associated aspartic protease 2]]

[[Category: Protease 2]]

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-'''Unreleased structure'''
+{{STRUCTURE_3wb5|  PDB=3wb5  |  SCENE=  }}
+===Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one===
+{{ABSTRACT_PUBMED_24051074}}
-The entry 3wb5 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Yonezawa, S., Fujiwara, K., Yamamoto, T., Hattori, K., Yamakawa, H., Muto, C., Hosono, M., Tanaka, Y., Nakano, T., Takemoto, H., Arisawa, M., Shuto, S.
+==About this Structure==
+[[3wb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WB5 OCA].
-Description: Crystal Structure of beta secetase in complex with (6S)-2-amino-3,6-dimethyl-6-[(1R,2R)-2-phenylcyclopropyl]-3,4,5,6-tetrahydropyrimidin-4-one
+==Reference==
+<ref group="xtra">PMID:024051074</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Arisawa, M.]]
+[[Category: Fujiwara, K.]]
+[[Category: Hattori, K.]]
+[[Category: Hosono, M.]]
+[[Category: Muto, C.]]
+[[Category: Nakano, T.]]
+[[Category: Shuto, S.]]
+[[Category: Takemoto, H.]]
+[[Category: Tanaka, Y.]]
+[[Category: Yamakawa, H.]]
+[[Category: Yamamoto, T.]]
+[[Category: Yonezawa, S.]]
+[[Category: Asp2]]
+[[Category: Hydrolase]]
+[[Category: Memapsin-2]]
+[[Category: Membrane-associated aspartic protease 2]]
+[[Category: Protease 2]]