4boq: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of OTUD2 OTU domain===

~~The entry 4boq~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.

~~Authors~~: ~~Mevissen, T~~.E.T.~~, Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M~~.V.~~, Ovaa, H~~.~~, Komander, D~~.

==About this Structure==

[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA].

~~Description~~: ~~Structure of OTUD2 OTU domain~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Ubiquitinyl hydrolase 1]]

[[Category: Akutsu, M.]]

[[Category: Arnaudo, N.]]

[[Category: Ekkebus, R.]]

[[Category: Elliott, P R.]]

[[Category: Freund, S M.V.]]

[[Category: Geurink, P P.]]

[[Category: Hospenthal, M K.]]

[[Category: Komander, D.]]

[[Category: Kulathu, Y.]]

[[Category: Mevissen, T E.T.]]

[[Category: Oualid, F El.]]

[[Category: Ovaa, H.]]

[[Category: Wauer, T.]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4boq|  PDB=4boq  |  SCENE=  }}
+===Structure of OTUD2 OTU domain===
+{{ABSTRACT_PUBMED_23827681}}
-The entry 4boq is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
-Authors: Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
+==About this Structure==
+[[4boq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA].
-Description: Structure of OTUD2 OTU domain
+==Reference==
+<ref group="xtra">PMID:023827681</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Ubiquitinyl hydrolase 1]]
+[[Category: Akutsu, M.]]
+[[Category: Arnaudo, N.]]
+[[Category: Ekkebus, R.]]
+[[Category: Elliott, P R.]]
+[[Category: Freund, S M.V.]]
+[[Category: Geurink, P P.]]
+[[Category: Hospenthal, M K.]]
+[[Category: Komander, D.]]
+[[Category: Kulathu, Y.]]
+[[Category: Mevissen, T E.T.]]
+[[Category: Oualid, F El.]]
+[[Category: Ovaa, H.]]
+[[Category: Wauer, T.]]
+[[Category: Hydrolase]]