2gz3: Difference between revisions

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[[Image:2gz3.gif|left|200px]]<br /><applet load="2gz3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2gz3.gif|left|200px]]
caption="2gz3, resolution 2.100&Aring;" />
 
'''Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with NADP and aspartate-semialdehyde'''<br />
{{Structure
|PDB= 2gz3 |SIZE=350|CAPTION= <scene name='initialview01'>2gz3</scene>, resolution 2.100&Aring;
|SITE= <scene name='pdbsite=AC1:Nap+Binding+Site+For+Residue+A+367'>AC1</scene>, <scene name='pdbsite=AC2:Nap+Binding+Site+For+Residue+B+367'>AC2</scene>, <scene name='pdbsite=AC3:Nap+Binding+Site+For+Residue+C+367'>AC3</scene>, <scene name='pdbsite=AC4:Nap+Binding+Site+For+Residue+D+367'>AC4</scene>, <scene name='pdbsite=AC5:As2+Binding+Site+For+Residue+A+400'>AC5</scene>, <scene name='pdbsite=AC6:As2+Binding+Site+For+Residue+B+400'>AC6</scene>, <scene name='pdbsite=AC7:As2+Binding+Site+For+Residue+C+400'>AC7</scene> and <scene name='pdbsite=AC8:As2+Binding+Site+For+Residue+D+400'>AC8</scene>
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=AS2:2-AMMONIO-4-OXOBUTANOATE'>AS2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11]
|GENE= asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
}}
 
'''Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with NADP and aspartate-semialdehyde'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2GZ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=AS2:'>AS2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] Known structural/functional Sites: <scene name='pdbsite=AC1:Nap+Binding+Site+For+Residue+A+367'>AC1</scene>, <scene name='pdbsite=AC2:Nap+Binding+Site+For+Residue+B+367'>AC2</scene>, <scene name='pdbsite=AC3:Nap+Binding+Site+For+Residue+C+367'>AC3</scene>, <scene name='pdbsite=AC4:Nap+Binding+Site+For+Residue+D+367'>AC4</scene>, <scene name='pdbsite=AC5:As2+Binding+Site+For+Residue+A+400'>AC5</scene>, <scene name='pdbsite=AC6:As2+Binding+Site+For+Residue+B+400'>AC6</scene>, <scene name='pdbsite=AC7:As2+Binding+Site+For+Residue+C+400'>AC7</scene> and <scene name='pdbsite=AC8:As2+Binding+Site+For+Residue+D+400'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZ3 OCA].  
2GZ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZ3 OCA].  


==Reference==
==Reference==
Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria., Faehnle CR, Le Coq J, Liu X, Viola RE, J Biol Chem. 2006 Oct 13;281(41):31031-40. Epub 2006 Aug 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16895909 16895909]
Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria., Faehnle CR, Le Coq J, Liu X, Viola RE, J Biol Chem. 2006 Oct 13;281(41):31031-40. Epub 2006 Aug 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16895909 16895909]
[[Category: Aspartate-semialdehyde dehydrogenase]]
[[Category: Aspartate-semialdehyde dehydrogenase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]


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