2h04: Difference between revisions

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[[Image:2h04.gif|left|200px]]<br /><applet load="2h04" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2h04.gif|left|200px]]
caption="2h04, resolution 2.300&Aring;" />
 
'''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''<br />
{{Structure
|PDB= 2h04 |SIZE=350|CAPTION= <scene name='initialview01'>2h04</scene>, resolution 2.300&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=4UN:{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID'>4UN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE= PTPRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2H04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=4UN:'>4UN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H04 OCA].  
2H04 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H04 OCA].  


==Reference==
==Reference==
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta., Amarasinghe KK, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. Epub 2006 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16759857 16759857]
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta., Amarasinghe KK, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. Epub 2006 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16759857 16759857]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: wpd-loop]]
[[Category: wpd-loop]]


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