4jc7: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jc7|  PDB=4jc7  |  SCENE=  }}
+===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===
-The entry 4jc7 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
-Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J.Z.
+==Function==
+[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
-Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis
+==About this Structure==
+[[4jc7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JC7 OCA].
+[[Category: Haeggstrom, J Z.]]
+[[Category: Niegowski, D.]]
+[[Category: Rinaldo-Matthis, A.]]
+[[Category: Leukotriene c4 synthase]]
+[[Category: Lipid biosynthesis]]
+[[Category: Lyase]]
+[[Category: Product analog]]

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