4jir: Difference between revisions
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{{STRUCTURE_4jir| PDB=4jir | SCENE= }} | |||
===Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat=== | |||
{{ABSTRACT_PUBMED_24100137}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | |||
==About this Structure== | |||
[[4jir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/> | |||
[[Category: Aldehyde reductase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Chen, K.]] | |||
[[Category: Hu, X.]] | |||
[[Category: Zhai, J.]] | |||
[[Category: Zhang, H..]] | |||
[[Category: Zhang, L.]] | |||
[[Category: Zhao, Y.]] | |||
[[Category: Zheng, X.]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Tim barrel]] | |||
Revision as of 06:48, 23 October 2013
Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat
Template:ABSTRACT PUBMED 24100137
Function
[ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
About this Structure
4jir is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhang L, Zhang H, Zhao Y, Li Z, Chen S, Zhai J, Chen Y, Xie W, Wang Z, Li Q, Zheng X, Hu X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). FEBS Lett. 2013 Oct 4. pii: S0014-5793(13)00726-6. doi:, 10.1016/j.febslet.2013.09.031. PMID:24100137 doi:https://dx.doi.org/10.1016/j.febslet.2013.09.031
