4jz0: Difference between revisions
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{{STRUCTURE_4jz0| PDB=4jz0 | SCENE= }} | |||
===X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN]] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. | |||
==About this Structure== | |||
[[4jz0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZ0 OCA]. | |||
[[Category: Glutamate carboxypeptidase II]] | |||
[[Category: Barinka, C.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Metallopeptidase]] | |||
Revision as of 09:32, 2 April 2014
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055
Function
[FOLH1_HUMAN] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
About this Structure
4jz0 is a 1 chain structure. Full crystallographic information is available from OCA.
