4kdo: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the hemagglutinin of ferret-transmissble H5N1 virus in complex with human receptor analog LSTc===

~~The entry 4kdo is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/Q6DQ33_9INFA Q6DQ33_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]

~~Authors~~: ~~Lu, X~~.~~, Shi, Y~~.~~, Zhang, W~~.~~, Zhang, Y~~.~~, Qi, J~~.~~, Gao, G~~.F.

==About this Structure==

[[4kdo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KDO OCA].

~~Description~~: ~~Crystal structure of the hemagglutinin of ferret-transmissble H5N1~~ virus ~~in complex with human receptor analog LSTc~~

==Reference==

[[Category: Unidentified influenza virus]]

[[Category: Gao, G F.]]

[[Category: Lu, X.]]

[[Category: Qi, J.]]

[[Category: Shi, Y.]]

[[Category: Zhang, W.]]

[[Category: Zhang, Y.]]

[[Category: Homotrimer]]

[[Category: Viral protein]]

[[Category: Virus attachment and membrane fusion]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4kdo|  PDB=4kdo  |  SCENE=  }}
+===Crystal structure of the hemagglutinin of ferret-transmissble H5N1 virus in complex with human receptor analog LSTc===
+{{ABSTRACT_PUBMED_23794001}}
-The entry 4kdo is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/Q6DQ33_9INFA Q6DQ33_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
-Authors: Lu, X., Shi, Y., Zhang, W., Zhang, Y., Qi, J., Gao, G.F.
+==About this Structure==
+[[4kdo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KDO OCA].
-Description: Crystal structure of the hemagglutinin of ferret-transmissble H5N1 virus in complex with human receptor analog LSTc
+==Reference==
+<ref group="xtra">PMID:023794001</ref><references group="xtra"/><references/>
+[[Category: Unidentified influenza virus]]
+[[Category: Gao, G F.]]
+[[Category: Lu, X.]]
+[[Category: Qi, J.]]
+[[Category: Shi, Y.]]
+[[Category: Zhang, W.]]
+[[Category: Zhang, Y.]]
+[[Category: Homotrimer]]
+[[Category: Viral protein]]
+[[Category: Virus attachment and membrane fusion]]