2h10: Difference between revisions

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[[Image:2h10.gif|left|200px]]<br /><applet load="2h10" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2h10.gif|left|200px]]
caption="2h10, resolution 1.75&Aring;" />
 
'''Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam'''<br />
{{Structure
|PDB= 2h10 |SIZE=350|CAPTION= <scene name='initialview01'>2h10</scene>, resolution 1.75&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TBE:TAZOBACTAM+INTERMEDIATE'>TBE</scene> and <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= bla, shv1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
}}
 
'''Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2H10 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae] with <scene name='pdbligand=TBE:'>TBE</scene> and <scene name='pdbligand=MA4:'>MA4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H10 OCA].  
2H10 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H10 OCA].  


==Reference==
==Reference==
Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates., Totir MA, Padayatti PS, Helfand MS, Carey MP, Bonomo RA, Carey PR, van den Akker F, Biochemistry. 2006 Oct 3;45(39):11895-904. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17002290 17002290]
Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates., Totir MA, Padayatti PS, Helfand MS, Carey MP, Bonomo RA, Carey PR, van den Akker F, Biochemistry. 2006 Oct 3;45(39):11895-904. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17002290 17002290]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: b-lactamase inhibitor]]
[[Category: b-lactamase inhibitor]]


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