4klz: Difference between revisions
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''' | ==Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis== | ||
<StructureSection load='4klz' size='340' side='right' caption='[[4klz]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4klz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLZ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5p21|5p21]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klz RCSB], [http://www.ebi.ac.uk/pdbsum/4klz PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN]] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN]] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ab, E]] | |||
[[Category: Andrews, M]] | |||
[[Category: Hoedemaeker, F J]] | |||
[[Category: Keizers, P H]] | |||
[[Category: Kobayashi, M]] | |||
[[Category: Manning, L]] | |||
[[Category: Rzepiela, A A]] | |||
[[Category: Shah, D M]] | |||
[[Category: Siegal, G]] | |||
[[Category: Tuin, A W]] | |||
[[Category: Gdp/gtp binding]] | |||
[[Category: Guanine nucleotide binding]] | |||
[[Category: Protein binding]] | |||
[[Category: Small gtpase]] | |||
Revision as of 14:40, 21 December 2014
Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
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