4km7: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4km7| PDB=4km7 | SCENE= }} | |||
===Human folate receptor alpha (FOLR1) at acidic pH, triclinic form=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. | |||
==About this Structure== | |||
[[4km7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM7 OCA]. | |||
[[Category: Homo sapiens]] | |||
[[Category: III, C E.Dann.]] | |||
[[Category: Kovach, A R.]] | |||
[[Category: Wibowo, A S.]] | |||
[[Category: 5-methyltetrahydrofolate]] | |||
[[Category: Antifolate]] | |||
[[Category: Folate receptor]] | |||
[[Category: Folate receptor alpha]] | |||
[[Category: Folate-conjugate]] | |||
[[Category: Folate]] | |||
[[Category: Folic acid]] | |||
[[Category: Folr1]] | |||
[[Category: Gpi-anchored protein on eukaryotic membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Transport protein]] | |||
Revision as of 21:03, 7 August 2013
Human folate receptor alpha (FOLR1) at acidic pH, triclinic form
Disease
[FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function
[FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
About this Structure
4km7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
