4kr6: Difference between revisions
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{{STRUCTURE_4kr6| PDB=4kr6 | SCENE= }} | |||
===Crystal structure of a 4-thiouridine synthetase - RNA complex=== | |||
{{ABSTRACT_PUBMED_24705700}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/THII_THEMA THII_THEMA]] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity). | |||
==About this Structure== | |||
[[4kr6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024705700</ref><references group="xtra"/><references/> | |||
[[Category: TRNA sulfurtransferase]] | |||
[[Category: Ficner, R.]] | |||
[[Category: Lakomek, K.]] | |||
[[Category: Neumann, P.]] | |||
[[Category: 4-thiouridine synthesis]] | |||
[[Category: Adenylation]] | |||
[[Category: Pp-loop motif]] | |||
[[Category: Sulfurtransferase]] | |||
[[Category: Thiouridine]] | |||
[[Category: Thump domain]] | |||
[[Category: Transferase-rna complex]] | |||
[[Category: Trna modification]] | |||
Revision as of 07:41, 23 April 2014
Crystal structure of a 4-thiouridine synthetase - RNA complex
Template:ABSTRACT PUBMED 24705700
Function
[THII_THEMA] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
About this Structure
4kr6 is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R. Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification. Nucleic Acids Res. 2014 Apr 5. PMID:24705700 doi:https://dx.doi.org/10.1093/nar/gku249
