4ksd: Difference between revisions
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{{STRUCTURE_4ksd| PDB=4ksd | SCENE= }} | |||
===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref> | |||
==About this Structure== | |||
[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Lama glama]] | |||
[[Category: Mus musculus]] | |||
[[Category: Xenobiotic-transporting ATPase]] | |||
[[Category: Caya, A.]] | |||
[[Category: Chang, G.]] | |||
[[Category: Cregger, C.]] | |||
[[Category: Doshi, R.]] | |||
[[Category: Falson, P.]] | |||
[[Category: Govaerts, C.]] | |||
[[Category: Grimard, V.]] | |||
[[Category: Lee, C-W.]] | |||
[[Category: Martinez, L.]] | |||
[[Category: Pardon, E.]] | |||
[[Category: Steyaert, J.]] | |||
[[Category: Swartz, D J.]] | |||
[[Category: Szewczyk, P.]] | |||
[[Category: Urbatsch, I.]] | |||
[[Category: Villaluz, M.]] | |||
[[Category: Ward, A.]] | |||
[[Category: Atp binding]] | |||
[[Category: Membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Transport protein]] | |||
[[Category: Transporter]] | |||
Revision as of 05:23, 1 August 2013
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
Function
[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]
About this Structure
4ksd is a 2 chain structure with sequence from Lama glama and Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
