4kvd: Difference between revisions
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{{STRUCTURE_4kvd| PDB=4kvd | SCENE= }} | |||
===Crystal structure of Aspergillus terreus aristolochene synthase complexed with (4aS,7S)-1,4a-dimethyl-7-(prop-1-en-2-yl)decahydroquinolin-1-ium=== | |||
{{ABSTRACT_PUBMED_23905850}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARIS_ASPTE ARIS_ASPTE]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.<ref>PMID:10775423</ref> <ref>PMID:15186158</ref> | |||
==About this Structure== | |||
[[4kvd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KVD OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023905850</ref><references group="xtra"/><references/> | |||
[[Category: Aristolochene synthase]] | |||
[[Category: Aspergillus terreus]] | |||
[[Category: Al-lami, N.]] | |||
[[Category: Allemann, R K.]] | |||
[[Category: Antonio, E L.D.]] | |||
[[Category: Cane, D E.]] | |||
[[Category: Chen, M.]] | |||
[[Category: Christianson, D W.]] | |||
[[Category: Faraldos, J A.]] | |||
[[Category: Janvier, M.]] | |||
[[Category: Class i terpene cyclase]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||